Regulators and Effectors of Small GTPases, Part F: Ras Family I: 332 (Methods in Enzymology)

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A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization. Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. Trends Cell Biol 16 : 27—35, Casanova JE. Regulation of arf activation: the sec7 family of guanine nucleotide exchange factors. Traffic 8 : —, Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation. EMBO J 30 : —, Chabre M.

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GEF what? Dock and related proteins help Rac to polarize cells in new ways. Trends Cell Biol 17 : —, Ras history: the saga continues. Small GTPases 1 : 2—27, Crossref Google Scholar Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J 23 : —, Mutations in GDI1 are responsible for X -linked non-specific mental retardation. Nat Genet 19 : —, A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.

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Regulators and Effectors of Small GTPases, Part E GTPases Involved in Vesicular Traffic, Volume 329

Amphipathic helices and membrane curvature. Asymmetric tethering of flat and curved lipid membranes by a golgin. Am J Hum Genet 87 : —, Mol Cell Neurosci 23 : —, Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes. Nat Rev Mol Cell Biol A Ras-induced conformational switch in the Ras activator Son of sevenless.


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Physiol Rev 91 : —, A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism. Legionella pneumophila proteins that regulate Rab1 membrane cycling. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J Cell Biol : —, Nat Chem Biol Nucleotide exchange via local protein unfolding: structure of Rab8 in complex with MSS4. EMBO J 25 : —, Sec2 is a highly efficient exchange factor for the Rab protein Sec4.

A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Jaffe AB , Hall A.

Regulators and Effectors of Small GTPases, Part F: Ras Family I - كتب Google

Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21 : —, Secrets of a successful pathogen: legionella resistance to progression along the autophagic pathway. Front Microbiol 2 : , Consensus nomenclature for the human ArfGAP domain-containing proteins. Ras oncogenes: split personalities.

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  • Asef, a link between the tumor suppressor APC and G-protein signaling. Protein Sci 19 : —, The kinetic mechanism of Ran—nucleotide exchange catalyzed by RCC1. Biochemistry 34 : —, Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry. Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1. Hum Mol Genet 7 : —, GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability.

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    Current Biol 18 : —, Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. Kubori T , Galan JE. Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradation. Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Structure 14 : —, Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis DOCK nucleotide exchange factors.

    Mol Cell Biol 29 : —, Nat Genet 26 : —, PLoS One 6 : e, Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm. Biochemistry 37 : —, SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations.

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    Identification of a DOCKrelated guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. Mol Biol Cell 12 : —, High catalytic efficiency and resistance to denaturing in bacterial Rho GTPase-activating proteins. Biol Chem : —, EMBO J Loirand G , Pacaud P. The role of Rho protein signaling in hypertension. Nat Rev Cardiol 7 : —, Nat Struct Mol Biol 11 : —, Curr Biol 15 : —, A bifunctional bacterial protein links GDI displacement to Rab1 activation.

    The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis. Hum Mol Genet 6 : —, Structure of RCC1 chromatin factor bound to the nucleosome core particle. Mol Cell 1 : —, Structural evidence for feedback activation by Ras. Characterisation of a novel TSC2 missense mutation in the GAP related domain associated with minimal clinical manifestations of tuberous sclerosis.

    J Med Genet 41 : e64, The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell 17 : —, The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdcbinding CZH2 domain. Menetrey J , Cherfils J. Proteins 37 : —, Tiam1 takes PARt in cell polarity. Trends Cell Biol 16 : —, Miller EA , Barlowe C.

    Regulation of coat assembly: sorting things out at the ER.